Artificial Gut Simulator: A Step Closer to In-Vitro In-Vivo Correlation?

09:05 - 09:40

  • Conventional dissolution apparatus is often neither optimal nor satisfactory for differentiating the drug release performance of formulations and predicting oral bioavailability
  • The need to integrate dissolution and absorption has become increasing apparent
  • A novel apparatus to maintain absorptive sink conditions with a large surface area-to-volume ratio of absorptive surface was developed to conduct simultaneous dissolution and absorption testing
  • The system has been tested and optimized with a model drug, Ketoconazole, to obtain the biorelevant absorption rate constant, ka

Helen Hao Hou, Senior Scientist Small Molecule Pharmaceutical Sciences , Genentech