Twin-Screw Melt Granulation of Thermally Labile Drug: Effect of Processing Conditions

16:30 - 17:05

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  • Processing temperature and reduction of GABA particle size during granulation are significant factors that can affect the chemical stability of GABA.
  • Small particle size of HPC can cause higher degradation due to higher surface area in contact with GABA particles.
  • Processing parameters (screw speed and feed rate) should be optimized to achieve the balance between improving compaction properties but still maintaining chemical stability of GABA.

Feng Zhang, Assistant Professor, University of Texas at Austin