7:40 AM - 8:40 AM

Registration & Refreshments

8:40 AM - 8:50 AM

Chair’s Opening Remarks

8:50 AM - 9:25 AM - Keynote

Small Molecules

Keynote (Session TBC)

9:30 AM - 10:05 AM - Case Studies

Small Molecules

Current Trends in Technology and Regulatory Landscapes for Developing and Bringing Generics and Innovative Medicines to Market

Rosario Lobrutto, Head of Scientific Affairs, Sandoz

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Device Development

Future Potential for Wearables

  • Key drivers for adopting wearables
  • Using data to design better treatments
  • Wearable drug delivery

10:10 AM - 10:45 AM - Solution Spotlights

Small Molecules

Session TBC (DuPont)

Biologics

Session TBC (Albumedix)

Device Development

Session TBC (Datwyler)

10:45 AM - 11:35 AM

iSolve & Networking Break

11:35 AM - 12:10 PM - Case Studies

Small Molecules

Solubility Strategies at the Interface of Drug Discovery and Development

Dr. Philippe Lienard, CMC Pre-Development Science Leader, Sanofi

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Biologics

Machine Learning Models for Predicting P-gp and BCRP Mediated Efflux

Istvan Enyedy, Principal Scientist, Biogen

The Design of therapeutic agents that penetrate the blood-brain barrier is challenging mainly due to the promiscuity of efflux transporters. The structures of P-gp and BCRP have been published allowing us to build machine learning models that combine the transporter structural information with traditional ligand-based descriptors. The performance of these models will be presented.

Device Development

12:15 PM - 12:50 PM - Solution Spotlights

Small Molecules

Session TBC (Foster Delivery Science)

Technology & Innovation

Session TBC (Lonza Pharma & Biotech)

Device Development

Session TBC (Enable Injections)

12:50 PM - 1:50 PM

Networking Lunch

1:35 PM - 2:10 PM - Case Studies

Small Molecules

Orthogonal Method to Determine the Glass Transition Temperatures of Commercial Biopharmaceutical Product

Biologics

Emerging Opportunities in Biologics Delivery

  • Changing regulatory landscape including paediatric regulations  
  • Demand in the market
  • Challenges in the industry to be addressed
  • The changing landscape of collaboration

Device Development

Software Applications (Apps), the New Medical Devices?

  • When do mobile apps become devices? The regulations.
  • Allowing apps to make recommendations on treatments or medical consultations
  • Role of AI and responsibility of app designers vs medical clinicians

2:15 PM - 2:50 PM - Solution Spotlights

Small Molecules

Quotient Sciences

Biologics

Session TBC (Biopharma group)

Device Development

Solution Spotlight (Session TBC)

2:50 PM - 3:40 PM

iSolve & Networking Break

3:40 PM - 4:55 PM - Case Studies

Small Molecules

Targeting Cancers with Nano Drug Delivery Systems

  • Understanding passive and active targeting strategies
  • Main challenges faced in with nanoparticle formulations
  • Overcoming instability of nanoparticles

Device Development

Wearable Insulin Delivery Devices

  • Sweat based glucose monitoring
  • Closed loop systems for glucose measurement and dosage setting
  • Data collection and deep learning

5:00 PM - 5:30 PM - Keynote

Panel Discussion: Preparing for Patient-Centric Drug Development Regulations

  • What do the recent FDA Guidelines on Patient-Focused Drug Development (PFDD) mean to us?
  • Why do we need more patient focussed thinking and design of drug products, medical devices and combination products?
  • How will become more patient focussed shake up the industry and make us more competitive

5:30 PM - 5:35 PM

Poster Presentation Award

DDF Poster 2019 Winner Announcement and Award Presentation

5:35 PM - 5:40 PM

Chair’s Closing Remarks

5:40 PM - 6:40 PM

Evening Drinks Reception

8:00 AM - 8:45 AM

Registration & Refreshments

8:45 AM - 8:50 AM

Chair’s Opening Remarks

8:50 AM - 9:25 AM - Keynote

Biologics

Combination Treatment of Multidrug Resistant Tumours with Stimuli-Sensitive Nanocarriers co-loaded with siRNA and Drugs

  • Co-loading drug and siRNA on the same delivery nanosystem
  • Creating stimuli-sensitive nanopreparation
  • Targeting organelles using nanodrugs 

9:30 AM - 10:05 AM - Case Studies

Small Molecules

Accelerated Stability Testing of Biopharmaceutical Excipients

  • Accelerated vs Real-Time testing techniques
  • Humidity and pH accelerated effects prediction
  • Current regulations for accelerated shelf life assessments

Biologics

Innovations in Creating Drugs for CNS Diseases

  • Overcoming the challenge of crossing the BBB (Blood Brain Barrier)
  • Case Studies on potential companion drugs
  • Formulating CNS drugs with built in S1P1 inhibitors

Device Development

Carbon Nanotube Composites for Drug Delivery

  • Overcoming biological barriers
  • Nanotube interactions with subcellular structures
  • Micro-Injector for solid micro-dose Injections: Regulatory Considerations for Pharmaceutical and Device Development

10:10 AM - 10:45 AM - Solution Spotlights

Small Molecules

Session TBC (Cydex Pharmaceuticals)

Technology & Innovation

Solution Spotlight (Session TBC)

Device Development

Solution Spotlight (Session TBC)

10:45 AM - 11:35 AM

iSolve & Networking Break

11:35 AM - 12:10 PM - Case Studies

Small Molecules

Optimizing Conventional Formulations for Continuous Manufacturing

  • Improving material science, API and process robustness for continuous manufacturing
  • Ensuring you have fully automated controls to realize true end-to-end pharma production
  • Breakthrough technologies poised to revolutionize formulation and manufacturing

Biologics

Exploiting Synthetic Peptides in Generic Development

  • Current status of synthetic peptide use
  • Improving peptide stability and formulations

Device Development

Challenges and Opportunities in Combination Product Design, Development and Use

12:15 PM - 12:50 PM - Solution Spotlights

Small Molecules

Session TBC (Leon-nanodrugs GmbH)

Biologics

Solution Spotlight (Session TBC) (1)

Device Development

Solution Spotlight (Session TBC) (2)

12:50 PM - 1:50 PM

Networking Lunch

1:35 PM - 2:10 PM - Case Studies

Small Molecules

Achieving better Success Rate at Developing CNS targeted drugs

  • How to overcome the stumbling block of pharmacokinetics/pharmacodynamics
  • Choosing more efficient dosages

Biologics

QbD and Process Scale Up Considerations

  • Biological continuous manufacturing
  • Making sense of regulatory guidelines
  • Formulating drugs with manufacturing in mind

Device Development

Medical Apps and a New Generation of Combination Products

  • The next logical step: How, why and when to include an app with your drug or device
  • What benefits can an app provide the patient
  • Regulations on apps and data

2:15 PM - 2:50 PM - Solution Spotlights

Small Molecules

Solution Spotlight (Session TBC) (3)

Technology & Innovation

Solution Spotlight (Session TBC) (4)

Device Development

Solution Spotlight (Session TBC) (5)

2:50 PM - 3:40 PM

Networking Break

3:40 PM - 4:15 PM - Case Studies

Small Molecules

Nanoparticles for targeted Tumour Drug Delivery

  • Improving stability of microparticle internalised chemotherapy
  • Potential to minimise systemic toxicity with new formulations

Biologics

Antibody-Drug Conjugates Formulation, Stabilisation

  • Formulating monoclonal antibody and the payload in unison
  • Improving characterisation and control of newer ADCs
  • Potential for hydrophobic drugs

Device Development

Ophthalmic Drug Delivery

  • Avoiding drug loss through thermoresponsive polymer formulation
  • in-vitro evaluation of ophthalmic drug release
  • Performance characteristics of ophthalmic drug delivery

4:20 PM - 4:55 PM - Case Studies

Small Molecules

Injectable Drug Formulation Depots with Sustained Release

  • Reducing relapse rates amongst all patients including non-complying patients
  • Achieving sustained release drugs through physiochemical alteration

Biologics

Novel CART Cell Therapy Based Tumour Treatments

  • Challenges and solutions to finding correct antigens
  • Overcoming hostile environment associated with tumours

Device Development

Development of Inhalers That Guide Patient Technique

  • Setting out the problem with improper inhaler use
  • Can we reduce the amount of medication lost from inhalers?
  • Programming smart inhalers to inform patients of medication adherence
  • Integrated sensors to warn patients of environmental asthma triggers

5:00 PM - 5:30 PM - Panel Discussion

Device Development

What does the future hold for novel drug delivery and combination products?

·         What are the current and anticipated hurdles to novel drug delivery?

·         What are the current biggest challenges to developing new combination products and how will this affect LCM?

·         How will new technology change current products (special focus on apps and connectivity)

5:30 PM - 5:35 PM

Chair’s Closing Remarks