Challenges and Impact of Formulation on Exposure to Drive PKPD in CNS Drug Discovery

Dr. Patrick Trapa leads the quantitative translation group within the DMPK department at Biogen. His team provides modeling and general project support for programs of all stages and modalities. Patrick received his bachelor’s and Ph.D. from MIT in Materials Science and Engineering and an M.B.A. from the University of Rhode Island. After completing his doctoral work, he co-founded a lithium polymer-battery company and later served as lecturer and research associate at MIT. During this time, he also consulted with NASA on high-temperature metallurgy projects. He then ran the specialty battery division at a publicly traded battery company before entering Pfizer in 2006. At Pfizer, Patrick held roles in preformulations as well as ADME, PK/PD, and systems modeling. He transitioned to Biogen in 2018.