Compatibility between Drug Formulation and Syringe / Autoinjector Performance

10 September 2019 13:50 - 14:25

  • Formulation matrix can impact silicone oil lubricity of syringe and PFS/AI functionality upon stability 
  • Accelerated stability data for glide force can predict refrigerated shelf life performance
  • Important to select right excipients to avoid negative impact on device performance stability
  • Syringe friction change is caused by dynamic interactions of formulation excipients with silicone oil, water and glass

Galen Shi, Senior Engineering Advisor, Eli Lilly