Inner Ear Drug Delivery: a case study on the Inner Ear Delivery of Neurotrophin-3

13:50 - 14:25

  • Overview of the inner ear drug delivery
  • A case study on the inner ear delivery of NT3, including (1) The electrophysiological response after dosing NT3 in a noise induced hearing loss mouse model; (2) The NT3 disposition in the perilymph; (3) The NT3 distribution in the cochlear tissue determined by radio-imaging methods; (4) The pharmacodynamic response in cochlea upon the inner ear dosing of NT3.
  • Future perspectives

Qi-Ying Hu, Director of Formulation and Drug Delivery, Decibel Therapeutics